A direct reconstruction algorithm for the anisotropic inverse conductivity problem based on Calderon's method in the plane

A direct reconstruction algorithm based on Calderon's linearization method for the reconstruction of isotropic conductivities is proposed for anisotropic conductivities in two-dimensions. To overcome the non-uniqueness of the anisotropic inverse conductivity problem, the entries of the unperturbed anisotropic tensors are assumed known a priori, and it remains to reconstruct the multiplicative scalar field. The quasi-conformal map in the plane facilitates the Calderon-based approach for anisotropic conductivities. The method is demonstrated on discontinuous radially symmetric conductivities of high and low contrast.Peer reviewe

BEST PROXIMITY POINTS IN NON - ARCHIMEDEAN FUZZY METRIC SPACES

In this article we establish best proximity point theorems for non-self proximal contractions in the setting of Non - Archimedean Fuzzy Metric Space which are more general than the notion of self-contractions. Then we present some examples to support our best proximity point theorems

Partial Purification and Biochemical Characterization of Extracellular Pectinase from Aspergillus Niger Isolated from Groundnut Seeds

To produce and partially purify pectinases from Aspergillus niger isolateJGIm2, characterize the enzymes for potential industrial applications in clarifying fruit juices. Methodology and results: Isolates of Aspergillus niger were screened for ability to produce pectinases by the enzymatic index method. All the 34 isolates screened were producers with isolates JGIm2, JGIm3 and JGIm5 being the best. Optimum enzyme production was found with medium containing 1.5% pectin after 48 h of fermentation. Partial purification of the enzyme was carried out by ethanol precipitation to give two fold purification and 56% yield. The enzyme had pH & temperature optima of 4.0 and 45°C, Km and Vmax values of 0.178 g/dl & 11.62 IU/mg protein, respectively. Clarification of banana and pineapple juice using the partially purified enzyme resulted in 38 and 41% reduction in viscosity as determined spectroscopically

Tucatinib vs Placebo, Both in Combination With Trastuzumab and Capecitabine, for Previously Treated ERBB2 (HER2)-Positive Metastatic Breast Cancer in Patients With Brain Metastases: Updated Exploratory Analysis of the HER2CLIMB Randomized Clinical Trial

Tucatinib; Càncer de mama metastàtic; Metàstasis cerebralTucatinib; Cáncer de mama metastásico; Metástasis cerebralTucatinib; Metastatic Breast cancer; Brain metastasesImportance: It is estimated that up to 50% of patients with ERBB2 (HER2)-positive metastatic breast cancer (MBC) will develop brain metastases (BMs), which is associated with poor prognosis. Previous reports of the HER2CLIMB trial have demonstrated that tucatinib in combination with trastuzumab and capecitabine provides survival and intracranial benefits for patients with ERBB2-positive MBC and BMs. Objective: To describe overall survival (OS) and intracranial outcomes from tucatinib in combination with trastuzumab and capecitabine in patients with ERBB2-positive MBC and BMs with an additional 15.6 months of follow-up. Design, setting, and participants: HER2CLIMB is an international, multicenter, randomized, double-blind, placebo-controlled clinical trial evaluating tucatinib in combination with trastuzumab and capecitabine. The 612 patients, including those with active or stable BMs, had ERBB2-positive MBC previously treated with trastuzumab, pertuzumab, and trastuzumab emtansine. The study was conducted from February 23, 2016, to May 3, 2019. Data from February 23, 2016, to February 8, 2021, were analyzed. Interventions: Patients were randomized 2:1 to receive tucatinib (300 mg orally twice daily) or placebo (orally twice daily), both in combination with trastuzumab (6 mg/kg intravenously or subcutaneously every 3 weeks with an initial loading dose of 8 mg/kg) and capecitabine (1000 mg/m2 orally twice daily on days 1-14 of each 3-week cycle). Main outcomes and measures: Evaluations in this exploratory subgroup analysis included OS and intracranial progression-free survival (CNS-PFS) in patients with BMs, confirmed intracranial objective response rate (ORR-IC) and duration of intracranial response (DOR-IC) in patients with measurable intracranial disease at baseline, and new brain lesion-free survival in all patients. Only OS was prespecified before the primary database lock. Results: At baseline, 291 of 612 patients (47.5%) had BMs. Median age was 52 years (range, 22-75 years), and 289 (99.3%) were women. At median follow-up of 29.6 months (range, 0.1-52.9 months), median OS was 9.1 months longer in the tucatinib-combination group (21.6 months; 95% CI, 18.1-28.5) vs the placebo-combination group (12.5 months; 95% CI, 11.2-16.9). The tucatinib-combination group showed greater clinical benefit in CNS-PFS and ORR-IC compared with the placebo-combination group. The DOR-IC was 8.6 months (95% CI, 5.5-10.3 months) in the tucatinib-combination group and 3.0 months (95% CI, 3.0-10.3 months) in the placebo-combination group. Risk of developing new brain lesions as the site of first progression or death was reduced by 45.1% in the tucatinib-combination group vs the placebo-combination group (hazard ratio, 0.55 [95% CI, 0.36-0.85]). Conclusions and relevance: This subgroup analysis found that tucatinib in combination with trastuzumab and capecitabine improved OS while reducing the risk of developing new brain lesions, further supporting the importance of this treatment option for patients with ERBB2-positive MBC, including those with BMs.This study was sponsored by Seagen Inc, Bothell, Washington, in collaboration with Merck Sharp & Dohme LLC, a subsidiary of Merck & Co, Inc, Rahway, New Jersey

Glue-infused Rotating Nanofibers Net (GRoNNet) for Capturing Space Debris - A Novel Debris Capturing System

As of January 2018, there were over 166 million pieces of space debris smaller than 1cm, ~750,000 pieces with size ranging from 1cm − 10cm and ~29,000 particles larger than 10cms. It is evident that space debris is a growing concern, particularly in the low altitude Earth orbits, and if not addressed in time, may have a drastic socio-economic impact on civilization. This paper describes the Glue-infused Rotating Nanofibers Net (GRoNNet), a novel debris capturing system for pico/nano/micro-satellites (PNMSats). GRoNNet is designed as a modular, cost-effective system with the capability to capture a target debris in multiple attempts and expedite its re-entry by attaching a debris mitigation system. It may be best described by comparing it with a chameleon’s tongue but several hundreds or thousands of them infused with a thick honey-like viscous adhesive in a rotary configuration, so as to adhere strongly with a target debris even at the slightest contact. The main components of GRoNNet are - (i) a tuft of braided nanofibers wound around a spool, (ii) a set of glue containers (resin and hardener) with electronic valves, (iii) a duct for facilitating the flow and infusing the nanofibers with glue, (iv) a microcontroller with a wireless communication link to the host satellite, (v) a power management system with battery, (vi) a LiDAR or a stereo camera for sensing the proximity of the target debris and (vi) a motor for rotating the glue-infused fibers. GRoNNet is envisioned as an autonomous module with a form factor of a 3U CubeSat and several such modules may be loaded onto a host satellite, which is primarily responsible for proximity and rendezvous operations. A GRoNNet module is deployed using a tether system when the host satellite is in close proximity with a target debris. The other end of the tether system connects to a passive deorbiting module through a mechanical umbilical. The GRoNNet module when commanded by the host satellite using the wireless link, activates the deployment of the braided activated carbon nanofibers, which are set in rotary motion by the onboard motor. Almost concurrently, the nanofibers are infused with a peptide-based space glue, which works particularly well when devoid of moisture. A successful capturing of the target debris is sensed by the host satellite through a load cell connected to the umbilical. Upon successfully capture, the tether system along with a passive de-orbiting module (UWDES, mDEMS) is launched out of the host satellite to expedite the re-entry of the target debris

Personalized Content Recommendations Across Devices Using Discover Tab

A television device includes a media application that displays a user interface that enables a user to select and launch media content across a variety of streaming platforms. The user interface includes a discover tab that provides personalized recommendations across a plurality of streaming platforms. For example, a media platform may obtain signals relating to the user’s entitlements (e.g., which service/application that the user has access to) and/or provider affinities (e.g., which service/application tends to user), and generate, using the signals, recommendations that are personalized to the user, where the recommendations include programs from multiple different streaming services. The recommendations are provided in the discover tab

NSs Encoded by Groundnut Bud Necrosis Virus Is a Bifunctional Enzyme

Groundnut bud necrosis virus (GBNV), a member of genus Tospovirus in the family Bunyaviridae, infects a large number of leguminosae and solanaceae plants in India. With a view to elucidate the function of nonstructural protein, NSs encoded by the small RNA genome (S RNA), the NSs protein of GBNV- tomato (Karnataka) [1] was over-expressed in E. coli and purified by Ni-NTA chromatography. The purified rNSs protein exhibited an RNA stimulated NTPase activity. Further, this activity was metal ion dependent and was inhibited by adenosine 5′ (β, γ imido) triphosphate, an ATP analog. The rNSs could also hydrolyze dATP. Interestingly, in addition to the NTPase and dATPase activities, the rNSs exhibited ATP independent 5′ RNA/DNA phosphatase activity that was completely inhibited by AMP. The 5′ α phosphate could be removed from ssDNA, ssRNA, dsDNA and dsRNA thus confirming that rNSs has a novel 5′ α phosphatase activity. K189A mutation in the Walker motif A (GxxxxGKT) resulted in complete loss of ATPase activity, but the 5′ phosphatase activity was unaffected. On the other hand, D159A mutation in the Walker motif B (DExx) resulted in partial loss of both the activities. These results demonstrate for the first time that NSs is a bifunctional enzyme, which could participate in viral movement, replication or in suppression of the host defense mechanism

Glue-Infused Rotating Nanofibers Net (GRoNNet) for Capturing Space Debris- A Novel Debris Capturing System

It is evident that space debris is a growing concern, particularly in the low altitude Earth orbits, and if not addressed in time, may have a drastic socio-economic impact on civilization. This paper describes the Glue-infused Rotating Nanofibers Net (GRoNNet), a novel debris capturing system for pico/nano/micro-satellites (PNMSats). GRoNNet is designed as a modular, cost-effective system with the capability to capture target debris in multiple attempts and expedite its re-entry by attaching a debris mitigation system. It may be best described by comparing it with a chameleon’s tongue but several hundreds/thousands of them infused with a thick honey-like viscous adhesive in a rotary configuration, so as to adhere strongly with target debris even at the slightest contact

Association of cataract and sun exposure in geographically diverse populations of India: The CASE study. First Report of the ICMR-EYE SEE Study Group.

PURPOSE: To determine the prevalence of cataract and its association with sun exposure and other environmental risk factors in three different geographically diverse populations of India. DESIGN: Population based cross sectional study during 2010-2016. PARTICIPANTS: People aged ≥ 40 years residing in randomly sampled villages were enumerated (12021) and 9735 (81%) underwent ophthalmic evaluation from plains, hilly and coastal regions (3595, 3231, 2909 respectively). METHODS: A detailed questionnaire-based interview about outdoor activity in present, past and remote past, usage of sun protective measures, exposure to smoke, and detailed ophthalmic examination including assessment of uncorrected and best corrected visual acuity, measurement of intraocular pressure, slit lamp examination, lens opacities categorization using LOCS III and posterior segment evaluation was done. Lifetime effective sun exposure was calculated using Melbourne formula and expressed as quintiles. These were supplemented with physical environmental measurements. MAIN OUTCOME MEASURES: Lifetime sun exposure hours, smoking, indoor kitchen smoke exposure and their association with cataract and subtypes. Prevalence of cataract calculated based on lens opacities or evidence of cataract surgery. RESULTS: Cataract was identified in 3231 (33.3%) participants. Prevalence of cataract in males (32.3%) and females (34.1%) was similar. Nuclear cataract was the commonest sub-type identified in 94.7% of affected eyes. Sun exposure had a significant association with cataract with odds ratio (OR) increasing from 1.6 (95% Confidence Intervals [CI]: 1.4, 1.9) in 3rd quintile, to 2.6 (CI: 2.2, 3.1) in 4th quintile and 9.4 (CI: 7.9, 11.2) in 5th quintile (p<0.0001). Cataract also showed a significant association with smoking (OR: 1.4, CI: 1.2, 1.6) and indoor kitchen smoke exposure (OR: 1.2, CI: 1.0-1.4). Nuclear cataract showed a positive association with increasing sun exposure in 3rd (β coefficient 0.5, CI:0.2-0.7), 4th (β: 0.9, CI: 0.7-1.1) and 5th (β: 2.1, CI:1.8-2.4) quintiles of sun exposure, smoking (β: 0.4, CI: 0.2-0.6) and indoor kitchen smoke exposure (β: 0.3, CI: 01-0.5) while cortical cataract showed a positive association with sun exposure only in 5th quintile (β: 2.6, CI:1.0-4.2). Posterior subcapsular cataract was not associated with any of the risk factors. CONCLUSION: Cataract is associated with increasing level of sun exposure, smoking and exposure to indoor kitchen smoke